Amantadine: an antiparkinsonian agent inhibits bovine brain 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme
Identifieur interne : 003C73 ( Main/Exploration ); précédent : 003C72; suivant : 003C74Amantadine: an antiparkinsonian agent inhibits bovine brain 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme
Auteurs : R. Kakkar [Canada] ; R. V. S. Raju [Canada] ; A. H. Rajput [Canada] ; R. K. Sharma [Canada]Source :
- Brain research [ 0006-8993 ] ; 1997.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Copyright (c) 1996 Elsevier Science B.V. All rights reserved. The effect of amantadine (an antiparkinsonian agent) on calmodulin-dependent cyclic nucleotide phosphodiesterase isozymes was investigated. Amantadine inhibited bovine brain 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase but not the bovine brain 63 kDa, heart and lung calmodulin-dependent cyclic nucleotide phosphodiesterase isozymes. The inhibition of bovine brain 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase was overcome by increasing the concentration of calmodulin. This suggests that amantadine may be an antagonist of calmodulin or act specifically and reversibly on the action of calmodulin. The bovine brain 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme is predominantly expressed in the brain and its inhibition may result in increased intracellular levels of cyclic AMP (cAMP). The increased intracellular levels of cAMP have a protective role for dopaminergic neurons. The present findings suggest that amantadine may be a valuable tool to investigate the physiological role of 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme in the progression of Parkinson"s disease and gives a new insight into the action of this drug.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000E99
- to stream PascalFrancis, to step Curation: 001024
- to stream PascalFrancis, to step Checkpoint: 000E00
- to stream Main, to step Merge: 004335
- to stream Main, to step Curation: 003C73
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Amantadine: an antiparkinsonian agent inhibits bovine brain 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme</title><author><name sortKey="Kakkar, R" sort="Kakkar, R" uniqKey="Kakkar R" first="R." last="Kakkar">R. Kakkar</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s2>Saskatoon S7N 4H4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon S7N 4H4</wicri:noRegion></affiliation></author><author><name sortKey="Raju, R V S" sort="Raju, R V S" uniqKey="Raju R" first="R. V. S." last="Raju">R. V. S. Raju</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s2>Saskatoon S7N 4H4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon S7N 4H4</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, A H" sort="Rajput, A H" uniqKey="Rajput A" first="A. H." last="Rajput">A. H. Rajput</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s2>Saskatoon S7N 4H4</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon S7N 4H4</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, R K" sort="Sharma, R K" uniqKey="Sharma R" first="R. K." last="Sharma">R. K. Sharma</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s2>Saskatoon S7N 4H4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon S7N 4H4</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">97-0215796</idno><date when="1997">1997</date><idno type="stanalyst">PASCAL 97-0215796 Elsevier</idno><idno type="RBID">Pascal:97-0215796</idno><idno type="wicri:Area/PascalFrancis/Corpus">000E99</idno><idno type="wicri:Area/PascalFrancis/Curation">001024</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000E00</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000E00</idno><idno type="wicri:doubleKey">0006-8993:1997:Kakkar R:amantadine:an:antiparkinsonian</idno><idno type="wicri:Area/Main/Merge">004335</idno><idno type="wicri:Area/Main/Curation">003C73</idno><idno type="wicri:Area/Main/Exploration">003C73</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Amantadine: an antiparkinsonian agent inhibits bovine brain 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme</title><author><name sortKey="Kakkar, R" sort="Kakkar, R" uniqKey="Kakkar R" first="R." last="Kakkar">R. Kakkar</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s2>Saskatoon S7N 4H4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon S7N 4H4</wicri:noRegion></affiliation></author><author><name sortKey="Raju, R V S" sort="Raju, R V S" uniqKey="Raju R" first="R. V. S." last="Raju">R. V. S. Raju</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s2>Saskatoon S7N 4H4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon S7N 4H4</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, A H" sort="Rajput, A H" uniqKey="Rajput A" first="A. H." last="Rajput">A. H. Rajput</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s2>Saskatoon S7N 4H4</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon S7N 4H4</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, R K" sort="Sharma, R K" uniqKey="Sharma R" first="R. K." last="Sharma">R. K. Sharma</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s2>Saskatoon S7N 4H4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon S7N 4H4</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno><imprint><date when="1997">1997</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>3′,5′-Cyclic-nucleotide phosphodiesterase</term><term>Amantadine</term><term>Animal</term><term>Antiparkinson agent</term><term>Brain (vertebrata)</term><term>Enzyme inhibitor</term><term>Isozyme</term><term>Ox</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Encéphale</term><term>Inhibiteur enzyme</term><term>3′,5′-Cyclic-nucleotide phosphodiesterase</term><term>Isozyme</term><term>Antiparkinsonien</term><term>Amantadine</term><term>Animal</term><term>Boeuf</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Copyright (c) 1996 Elsevier Science B.V. All rights reserved. The effect of amantadine (an antiparkinsonian agent) on calmodulin-dependent cyclic nucleotide phosphodiesterase isozymes was investigated. Amantadine inhibited bovine brain 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase but not the bovine brain 63 kDa, heart and lung calmodulin-dependent cyclic nucleotide phosphodiesterase isozymes. The inhibition of bovine brain 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase was overcome by increasing the concentration of calmodulin. This suggests that amantadine may be an antagonist of calmodulin or act specifically and reversibly on the action of calmodulin. The bovine brain 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme is predominantly expressed in the brain and its inhibition may result in increased intracellular levels of cyclic AMP (cAMP). The increased intracellular levels of cAMP have a protective role for dopaminergic neurons. The present findings suggest that amantadine may be a valuable tool to investigate the physiological role of 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme in the progression of Parkinson"s disease and gives a new insight into the action of this drug.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Kakkar, R" sort="Kakkar, R" uniqKey="Kakkar R" first="R." last="Kakkar">R. Kakkar</name></noRegion><name sortKey="Rajput, A H" sort="Rajput, A H" uniqKey="Rajput A" first="A. H." last="Rajput">A. H. Rajput</name><name sortKey="Raju, R V S" sort="Raju, R V S" uniqKey="Raju R" first="R. V. S." last="Raju">R. V. S. Raju</name><name sortKey="Sharma, R K" sort="Sharma, R K" uniqKey="Sharma R" first="R. K." last="Sharma">R. K. Sharma</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C73 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003C73 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:97-0215796
|texte= Amantadine: an antiparkinsonian agent inhibits bovine brain 60 kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme
}}
| This area was generated with Dilib version V0.6.29. |  |